THE PHARMACOLOGICAL EFFECTS OF TRITERPENOIDS FROM GANODERMA
LUCIDUM AND THE REGULATION OF ITS BIOSYNTHESIS
Journal: Open Journal of Chemical Engineering (OJCE)
Author: Haiden Lawrence
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
The paper aims to focus on bioactivities and potential applications of GAs, and the elicitation strategies for GA production are also highlighted based on the fundamental role of ROS, JA, Ca2+ and NO, which would shed light to developing a novel approach to manipulating the biosynthesis of GA in the future. The biosynthesis of GA in G. lucidum is induced by stressors including various elicitors or signaling molecules, and artificially placing elicitors would enhance GA production. From the perspective of pharmacology, those secondary metabolites have many biological activities, which include antitumor, antimicrobial, anti-malaria, antihepatotoxic and blood pressure reduction activity. From the aspect from fungi, the main function of secondary metabolites is adaptive responses to biotic or abiotic stresses. Application of elicitors into in vitro cultures would mimic the biotic or abiotic attacks, resulting in the biosynthesis of secondary metabolites.